Prototype 2 puts players in the role of Sgt James Heller, an infected soldier who sets out to kill Alex Mercer after losing his wife and child. The story unfolds in New York Zero, an open-world city fractured by the viral outbreak and conflict among its factions. Its three zones range from a militarized district and crowded refugee camps to a war-ravaged area overtaken by infection.
Heller’s powers make the city a hunting ground. He can use a sonar pulse to locate enemies, then absorb people to take on their disguises, memories, and abilities. Tendrils let him tear apart vehicles and groups of foes, while mutation perks offer choices such as faster movement, sharper claws, or improved disguise. These systems connect combat, hunting, and infiltration through Heller’s ability to change form and build a genetic arsenal.
Its open-world design also includes gliding and parkour across the city, alongside encounters with infected creatures and Blackwatch soldiers. The focus stays on Heller’s pursuit of Mercer and the evolving set of biological weapons and abilities he gains along the way.