No More Heroes follows Travis Touchdown, an otaku who finds himself ranked eleventh in the United Assassins Association and sets out to become its top assassin. His route upward runs through ten rival killers, giving the action a clear tournament-like goal. The game frames that climb with a deliberately offbeat cast and a coastal-city setting: Santa Destroy is not merely a backdrop for the fights, but a place Travis also rides through on his motorbike.
Combat centers on a beam katana, with Travis cutting through groups of enemies before facing professional-killer rivals. The fighting also includes pro-wrestling moves such as Power Bombs and Brain Busters, plus a Dark Side power. The store description characterizes the combat as easy to pick up but deeper to master, suggesting a blend of immediate action and room to learn its system rather than a purely button-mashing brawl.
Between ranking battles, Travis takes part-time jobs to earn money for merchandise and undergoes training to improve his abilities. That alternation between errands, preparation, roaming the city and high-stakes duels gives No More Heroes a distinct rhythm beyond continuous combat.