Infestation: The New Beginning casts players as survivors in a desolate countryside, where staying alive means exploring cities, scavenging for supplies and confronting threats. Its setting is described as a huge, persistent, nonlinear open world, giving the survival premise room to unfold across a broad landscape rather than a sequence of isolated encounters.
The design pairs cooperation with risk. Players can group together to improve their chances, while the online game also includes PvP. Loot has practical stakes: survivors can sell recovered items at a flea market, and an ATM system puts in-game currency at risk unless it is banked. The threat roster includes Super Zombies, Slicer Zombies and Zombie Dogs, with airdrops, radiation zones and helicopter crash sites identified as loot locations. The listed Oregon map is described as the size of Colorado.
It is one lens on a game whose central loop combines exploration, scavenging, combat and the choice to face danger with others.