Hentai vs Virus: I Am Waifu is an action game built around a zombie outbreak: a dangerous virus turns people into zombies, and the player takes the role of a cute anime girl trying to help save the world. The mission blends direct combat with city exploration, giving the fight a broader objective than simply clearing infected enemies.
Shooting is the central activity, with four types of weapons available for survival against the zombies. The city also contains secret objects to find, while destroying virus roots adds a specific target beyond the infected themselves. Character presentation is customizable through three different skins, and the game highlights its animation system as part of the action.
The store lists the game as single-player, so its play format is a solo campaign rather than a shared multiplayer session. Partial controller support is listed, alongside Steam achievements and trading cards.